# Tirzepatide Medicine

> A working chronicle of the tirzepatide evidence base — every SURPASS, every SURMOUNT, in plain prose.

## Pages

- [Tirzepatide Medicine — Independent reporting on the tirzepatide evidence base](/index.md): A reader-friendly summary of tirzepatide: how the dual GIP/GLP-1 receptor agonist works, what the SURPASS and SURMOUNT trials actually showed, and what the FDA has approved it for. Not medical advice.
- [Tirzepatide Reported Effects, Benefits & Safety — Community Reports and Cited Cautions](/effects.md): What people report on tirzepatide (anecdotal, not clinical evidence) and what the clinical and pharmacovigilance literature says about safety cautions — from GI tolerability to thyroid warning to lean-mass loss.
- [Tirzepatide Trials — SURPASS, SURMOUNT, SUMMIT and SYNERGY-NASH summaries](/research.md): Trial-by-trial summary of the tirzepatide evidence base: mechanism, SURPASS diabetes trials, SURMOUNT obesity trials, SUMMIT in heart failure, SYNERGY-NASH in liver disease, and SURPASS-CVOT.
- [Tirzepatide Dosing — FDA-label titration schedule and pharmacokinetics](/dosage.md): An editorial summary of how tirzepatide is dosed: the 2.5 mg starting dose, the 4-week titration intervals, the maintenance doses, and the pharmacokinetic profile. Not medical advice.
- [Tirzepatide FAQ — The questions people actually ask](/faq.md): Plain-language answers to the questions readers send us about tirzepatide: how it differs from semaglutide, what to expect from titration, what the side-effect profile looks like, and what happens when you stop.
- [Tirzepatide References — Cited literature with DOIs](/references.md): Full citation list for every tirzepatide claim on this site, with DOIs and PMC links to NEJM, Lancet, JAMA, Nature Medicine, JCI Insight, PNAS, and the FDA label.
- [About Tirzepatide Medicine — Editorial standards and disclosures](/about.md): Who runs this site, what it is, and what it is not. An independent editorial chronicle of the tirzepatide evidence base — not a clinic, not a vendor, not a marketing site.
- [Contact Tirzepatide Medicine — Corrections, questions, and editorial feedback](/contact.md): How to reach the editors of Tirzepatide Medicine — for corrections, citation requests, or editorial feedback. We do not provide medical advice or vendor referrals.